Technical parameters of Semax peptide:

Name of substance: Semax
Type of relationship: Synthetic peptide - a heptapeptide analogue of the ACTH fragment (4-10) with a terminal Pro-Gly-Pro motif
Amino acid sequence: Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP)
Summary formula: C₃₇H₅₁N₉O₁₀S.
Molecular weight: ~813.9 g/mol
CAS number: 80714-61-7
Physical form: White or almost white powder after freeze-drying
Solubility: soluble in aqueous solutions

What is the difference between standard Semax peptide and N-Acetyl Semax Amidate?

Standard peptide Semax is different from N-Acetyl Semax Amidate primarily chemical modifications at the ends of the peptide chain, which affect its stability and physicochemical properties. In its classical form, Semax has a free amino group at the N end and a free carboxyl group at the C end, while in the N-Acetyl Semax Amidate variant, the N end is acetylated and the C end is amidated. Such modifications reduce the susceptibility of the molecule to exopeptidases, reduce the net charge of the peptide at physiological pH, and may affect its solubility and stability profile in aqueous solutions. From a laboratory research point of view, N-Acetyl Semax Amidate is sometimes regarded as a more stable structural analogue, preferred in long-term experiments or procedures requiring better resistance to enzymatic degradation.

Product quality (N-Acetyl Semax Amidate , 20 mg)

Our Semax peptide product has been tested by a certified Polish laboratory. The results can be seen in the product gallery.

What does the product package (N-Acetyl Semax Amidate , 20 mg) contain?

The ordered product will come packaged in a sturdy tube resistant to transport damage, and inside it you will find:

Powder vial of 10 ml (Mannitol + N-Acetyl Semax Amidate 20 mg + 5 mg GHK-Cu arginate)
Vial of fluid 10 ml (saline with 3%DMSO)
Atomizer (for spraying a portion of the solution onto a laboratory slide)
Funnel (helps pour solvent into the peptide vial)

It is worth noting that the lyophilized powder will be white and blue in color due to the presence of the GHK-Cu peptide. The volume of powder in the vial may seem small, but this does not affect the peptide content measured in milligrams.

The safety data sheet (SDS) for this product can be downloaded here

How to prepare the solution for the laboratory test?

unscrew the stoppers from both vials
Transfer the liquid from the liquid vial to the powder vial
cap the vial with the powder with the original stopper
Mix carefully (no sudden movements)
unscrew the cap, remove the ring from the seal (important to keep it tight) and screw on the atomizer

We obtained 10 ml of solution, which is enough for about 70 atomizer presses of 285 mcg N-Acetyl Semax Amidate.

Storage and transportation

In dry form, the peptide should be stored at room temperature away from direct sunlight. Even longer transportation by courier will not affect the stability and quality of the product.

In wet form (after preparing the solution), the peptide should be in the refrigerator all the time and used up within 40 days.

Research use of the product (N-Acetyl Semax Amidate , 20 mg)

N-Acetyl Semax Amidate is intended for in vitro research use only. In a laboratory environment, it can be used as a research reagent, in particular for:

research conducted at the molecular and cellular level, requiring precise work with small amounts of peptide;
analyses of intracellular signaling pathways;
expression analysis of selected biological markers in cell models;
evaluation of the interaction of short peptide sequences with selected protein complexes, including those present in cells with a neuron-like phenotype;
conducting comparative studies and optimization procedures requiring stable, homogeneous, and appropriately characterized test preparations;
observation of droplets, sediments, and crystal structures using optical and polarizing microscopy;
analyses of the size and distribution of droplets produced by the atomizer, including by applying samples to laboratory slides;
evaluation of the size and distribution of aggregates present in the solution by dynamic light scattering (DLS);
conducting spectrophotometric analyses using the UV-Vis method, within a range appropriate for the properties of the tested peptide and the analytical method used.

Disclaimer

The product is not a drug, food product or dietary supplement. The product is classified as a chemical reagent/reference material authorized in the European Union under the European REACH Act, and can only be used for laboratory scientific research.