What is the TB-500?

TB-500 (43 aa) is a synthetic peptide consisting of 43 amino acids, corresponding to the full sequence of endogenous Thymosin β4 (Tβ4) - a protein naturally found in eukaryotic tissues and involved in the regulation of cell cytoskeleton dynamics. This compound has been characterised as a model peptide in studies of cell migration, actin filament reorganisation and tissue remodelling processes. By retaining the complete amino acid sequence of thymosin beta-4, TB-500 shows high structural compatibility with the endogenous form, making it a useful research tool.

In experimental studies, TB-500 has been used to analyse mechanisms related to actin polymerisation, cell adhesion and regulation of cell migration in in vitro and in vivo models. Its involvement in the modulation of structural and regulatory protein expression was described, as well as in processes related to angiogenesis, cellular response to mechanical injury and extracellular matrix remodelling. Attention was also drawn to its indirect interactions with selected signalling pathways involved in inflammatory response and repair processes.

Due to its unambiguous chemical structure, full sequence compatibility with endogenous thymosin beta-4 and high reproducibility of the observed biological effects, TB-500 is used as a research tool in cell biology, molecular biology and experimental pharmacology. In the scientific literature, it is sometimes used as a reference peptide in studies of cell migration, cytoskeletal reorganisation and in the validation of analytical methods used to evaluate bioactive peptides. The preparation is intended for research work only.

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Products in this category are not medicines, foodstuffs or dietary supplements. The products are classified as chemical reagents/reference materials authorised for marketing within the European Union and may be used exclusively for laboratory scientific research.