What is Epithalon?

Epitalone (Epithalon) is a synthetic peptide with a short sequence of four amino acids (Ala-Glu-Asp-Gly), designed as a stabilized form of fragments of natural peptides isolated from pineal tissue. Since the 1990s, this compound has been the subject of research focusing on regulatory mechanisms related to the rhythmicity of biological processes and the maintenance of functional balance at the cellular level. Its small molecular weight, precisely defined chemical structure and good solubility in aqueous media have made epithalon a useful model for studying peptide signaling independent of classical neurotransmitter systems.

In preclinical studies, epithalon has been used to evaluate processes related to cell cycle regulation, the ability of cells to adapt under environmental stress, and the maintenance of functional stability in long-term cultures. Scientific publications have described its involvement in the modulation of the expression of selected regulatory genes, its effects on the activity of enzyme systems involved in cellular metabolism, as well as potential effects on mechanisms related to telomere length and telomerase function in experimental models. These studies were conducted both in vitro and in selected in vivo systems.

Due to its clearly defined molecular composition and the high reproducibility of results obtained in research models, epitalone is used as an experimental tool in studies in molecular biology, cell biology and experimental gerontology. The peptide is also sometimes used as a reference compound in gene expression analyses, studies of cellular adaptive mechanisms and in validation procedures of analytical methods designed to evaluate short regulatory peptides. The product is intended for research use only.

Technical parameters of Epithalon peptide:

Name of substance: Epitalon (Epithalon)
Type of relationship: synthetic peptide - tetrapeptide analogue of fragments of natural peptides of pineal origin
Amino acid sequence: Ala-Glu-Asp-Gly (AEDG)
Summary formula: C₁₄H₂₂N₄O₉.
Molecular weight: ~390.4 g/mol
CAS number: 307297-39-8
Physical form: White or almost white powder after freeze-drying
Solubility: Well soluble in aqueous solutions

Product quality (Epitalon 100 mg + Bacteriostatic water)

Our Epitalon peptide product has been tested by a certified Polish laboratory. The results can be seen in the product gallery

What does the product package (Epitalon 100 mg + Bacteriostatic water) contain?

The ordered product will come packaged in a sturdy tube resistant to transport damage, and inside it you will find:

10 pieces sterile vials with Epitalon acetate 10mg powder + (peptide stabilizer - mannitol)
10 pieces sterile vials with 3 ml bacteriostatic water (0.9% benzyl alcohol)

The product has an expiration date of a minimum of one year and a maximum of two years from the date of shipment - depending on the batch.

The safety data sheet (SDS) for this product can be downloaded here

How to prepare the solution for the laboratory test?

Remove the cap from the water vial and the cap from the peptide vial.
Apply spirit to a cotton swab and disinfect the rubber bands in both vials.
Using an insulin syringe, pour 0.4 ml of bacteriostatic water into the powder vial (along the wall of the vessel)
Roll the vial in your hands or spin the vial making a vortex until the solution dissolves. This activity can be done vigorously, it is important not to foam the solution with strong shaking.
This prepared solution gives us a concentration of 10 mg of Epitalon peptide per vial, which should be stored in the refrigerator from now on

Storage and transportation

In dry form, the peptide should be stored at room temperature away from direct sunlight. Even longer transportation by courier will not affect the stability and quality of the product.

In wet form (after preparing the solution), the peptide should be in the refrigerator all the time and used up within 30 days.

If there are problems with the solubility of the peptide then:

Temporarily heat the solution to 25-37 degrees celcius (safe for the peptide)
Add more solvent
Several times the solution is slowly withdrawn into a syringe and dropped back into the vial.

These steps solve 90% solubility problems.

Disclaimer

The product is not a drug, food product or dietary supplement. The product is classified as a chemical reagent/reference material authorized in the European Union under the European REACH Act, and can only be used for laboratory scientific research. Educational materials about the substance Epitalon posted on our site are written on the basis of scientific research on the substance. These studies were performed by qualified scientific centers around the world and are not product specific.